Exclusive: T.R. Knight negotiating 'Grey's Anatomy' exit  —  The revolving door at Grey's Anatomy has taken another shocking spin.  —  Multiple sources confirm that T.R. Knight has asked to be released from his contract, a request that both ABC and Grey's show-runner Shonda Rhimes appear poised to grant.

Jennifer Aniston exclusive: Friends star talks for the first time about John Mayer  —  She may have had her heart shredded by the world's sexiest man but Jennifer Aniston keeps coming back for more.  —  And this time the actress - who loved and lost Hollywood heartthrob Brad Pitt - hasn't just fallen head over heels again.

Ruffalo Dies  —  Scott Ruffalo, the brother of actor Mark Ruffalo, died last night after suffering a gunshot wound last week.  —  Brian Scofield and Shaha Mishaal Adham turned themselves in to the Bev Hills PD yesterday.  Adham was named a “suspect” and Scofield was named a"person of interest" in the shooting.

LA PAPER TRAIL  —  MARIAH Carey's wish may finally be coming true.  Spies in LA saw the songbird (above) coming out of a well-known ob/gyn's office on North Crescent Boulevard, “clutching what looked like a sonogram and being greeted by her entourage with cheers.  She was ebullient.”

Tom Cruise Tells Spencer Pratt He Made Wedding Mistake  —  The Hills - MTV Shows  —  In a pre-taped interview on Monday's i>Hills after-show, Tom Cruise was asked what advice he had for Spencer Pratt, who famously eloped with Heidi Montag Nov. 24.  —  Cruise said that Pratt …

Oprah Winfrey Admits to Tipping the Scales at 200 Lbs.  —  Oprah Winfrey Dec. 5  —  Having packed 40 pounds onto her former 160-pound self, Oprah Winfrey is declaring, “I'm mad at myself” because she's “fallen off the wagon.”  —  As the media mogul, 54, writes in the January issue …

Britney's Dancers Getting Drug Tested  —  Who knew that the first thing you would hear after being hired to dance for Britney Spears would be, “Fill this, please.”  —  A source tells E! News that, in an effort to keep the on-track pop star free from negative influences …

Ashlee: Rock-a-Bye Bye Baby  —  After giving birth to son Bronx an entire 18 days ago, Ashlee Simpson did what every new mom does ... she went clubbing in West Hollywood.  —  Ash checked out her husband Pete Wentz's show at the Troubadour and then hightailed it next door to Foxtail for a little see and be scene action.

Fantasia — Foreclosure's Just a Fantasy!  —  Fantasia Barrino says reports she's about to lose a house are hogwash.  —  Reports say the “AI” winner is about to lose one of her homes in Charlotte, NC: She bought the 6-bed, 6,000-sq. ft. mansion back in 2007 for $1.3 mil (not a misprint) but couldn't keep up on payments.

PAM'S WOBBLY FLA. WEEKEND  —  PAMELA Anderson tore up Miami during her weekend trip to Art Basel to support her good pal David LaChapelle.  Anderson first went to the Miami Convention Center on Saturday to pose for photos with LaChapelle in front of his “Jesus Is My Homeboy” exhibit …

Anne Hathaway's wedding wish  —  Anne Hathaway wants to get married.  —  The ‘Bride Wars’ star - who split from long-term boyfriend Raffaello Follieri earlier this year - hopes to settle down one day but admits her previous experiences have left her wary of commitment.