Jennifer Aniston exclusive: Friends star talks for the first time about John Mayer  —  She may have had her heart shredded by the world's sexiest man but Jennifer Aniston keeps coming back for more.  —  And this time the actress - who loved and lost Hollywood heartthrob Brad Pitt - hasn't just fallen head over heels again.

Exclusive: T.R. Knight negotiating 'Grey's Anatomy' exit  —  The revolving door at Grey's Anatomy has taken another shocking spin.  —  Multiple sources confirm that T.R. Knight has asked to be released from his contract, a request that both ABC and Grey's show-runner Shonda Rhimes appear poised to grant.

Tom Cruise Tells Spencer Pratt He Made Wedding Mistake  —  The Hills - MTV Shows  —  In a pre-taped interview on Monday's i>Hills after-show, Tom Cruise was asked what advice he had for Spencer Pratt, who famously eloped with Heidi Montag Nov. 24.  —  Cruise said that Pratt …

Ruffalo Dies  —  Scott Ruffalo, the brother of actor Mark Ruffalo, died last night after suffering a gunshot wound last week.  —  Brian Scofield and Shaha Mishaal Adham turned themselves in to the Bev Hills PD yesterday.  Adham was named a “suspect” and Scofield was named a"person of interest" in the shooting.

LA PAPER TRAIL  —  MARIAH Carey's wish may finally be coming true.  Spies in LA saw the songbird (above) coming out of a well-known ob/gyn's office on North Crescent Boulevard, “clutching what looked like a sonogram and being greeted by her entourage with cheers.  She was ebullient.”

Ashlee: Rock-a-Bye Bye Baby  —  After giving birth to son Bronx an entire 18 days ago, Ashlee Simpson did what every new mom does ... she went clubbing in West Hollywood.  —  Ash checked out her husband Pete Wentz's show at the Troubadour and then hightailed it next door to Foxtail for a little see and be scene action.

Oprah Winfrey Admits to Tipping the Scales at 200 Lbs.  —  Oprah Winfrey Dec. 5  —  Having packed 40 pounds onto her former 160-pound self, Oprah Winfrey is declaring, “I'm mad at myself” because she's “fallen off the wagon.”  —  As the media mogul, 54, writes in the January issue …

Katy Perry Apologizes to Lily Allen for Weight Jab  —  Katy Perry is apologizing to Lily Allen for calling herself a “skinnier version” of the Brit singer.  —  “Yeah, I made a joke about [that] earlier this year,” Perry, 24, told Usmagazine.com exclusively at the taping of Fuse's The Good, the Bad & the Britney Tuesday.

Exclusive: Who's Gay on 90210?  —  It's a girl!  —  After all our guesses about which male character (Navid?  Ty?  That blond guy?) would come out of the closet on 90210, it's cheerleader Christina Worthy who is the same-sex-oriented cast member, sources tell TVGuide.com exclusively.

Paula Abdul Lashes Out at Idol Producers  —  Paula Abdul is blaming American Idol producers for allowing known stalker Paula Goodspeed to get close to her.  —  Abdul, in a Sirius XM radio interview on Barbara Live! with Barbara Walters Monday night, said that she was familiar with Goodspeed …

In Touch Exclusive: It's a girl for Trista and Ryan  —  Bachelorette Trista Sutter and her firefighter husband, Ryan, are thrilled to learn they are having a baby girl.  “We found out a few weeks ago,” Trista tells In Touch exclusively.  “It was such a fun surprise.

Britney's Dancers Getting Drug Tested  —  Who knew that the first thing you would hear after being hired to dance for Britney Spears would be, “Fill this, please.”  —  A source tells E! News that, in an effort to keep the on-track pop star free from negative influences …

Watch Jessica Biel Strip  —  In her upcoming drama Powder Blue (out next year), Jessica Biel takes it off as a woman who strips to raise her terminally ill son.  —  In the trailer (above), she dances, cracks eggs on her chest, does splits and hangs upside down from a pole.

Ben Affleck eyes Arizona territory  —  He'll helm adaptation of murdered reporter's tale  —  In the annals of journalism, most people's memories begin and end with the publication of the Pentagon Papers and the Watergate investigation.  But if some serious-minded Hollywood filmmakers have their say …