Exclusive: T.R. Knight negotiating 'Grey's Anatomy' exit  —  The revolving door at Grey's Anatomy has taken another shocking spin.  —  Multiple sources confirm that T.R. Knight has asked to be released from his contract, a request that both ABC and Grey's show-runner Shonda Rhimes appear poised to grant.

Ruffalo Dies  —  Scott Ruffalo, the brother of actor Mark Ruffalo, died last night after suffering a gunshot wound last week.  —  Brian Scofield and Shaha Mishaal Adham turned themselves in to the Bev Hills PD yesterday.  Adham was named a “suspect” and Scofield was named a"person of interest" in the shooting.

LA PAPER TRAIL  —  MARIAH Carey's wish may finally be coming true.  Spies in LA saw the songbird (above) coming out of a well-known ob/gyn's office on North Crescent Boulevard, “clutching what looked like a sonogram and being greeted by her entourage with cheers.  She was ebullient.”

Jennifer Aniston exclusive: Friends star talks for the first time about John Mayer  —  She may have had her heart shredded by the world's sexiest man but Jennifer Aniston keeps coming back for more.  —  And this time the actress - who loved and lost Hollywood heartthrob Brad Pitt - hasn't just fallen head over heels again.

Tom Cruise Tells Spencer Pratt He Made Wedding Mistake  —  The Hills - MTV Shows  —  In a pre-taped interview on Monday's i>Hills after-show, Tom Cruise was asked what advice he had for Spencer Pratt, who famously eloped with Heidi Montag Nov. 24.  —  Cruise said that Pratt …

Oprah Winfrey Admits to Tipping the Scales at 200 Lbs.  —  Oprah Winfrey Dec. 5  —  Having packed 40 pounds onto her former 160-pound self, Oprah Winfrey is declaring, “I'm mad at myself” because she's “fallen off the wagon.”  —  As the media mogul, 54, writes in the January issue …

Brad Pitt Says Kids Haven't Necessarily Changed His Mind On Marriage  —  Brad Pitt,Angelina Jolie,Maria Menounos,Access Hollywood,Chuck  —  Brad Pitt and Angelina Jolie have six kids together and they have hinted that their family could continue to grow, but that doesn't mean Brad and Angelina …

Ashlee: Rock-a-Bye Bye Baby  —  After giving birth to son Bronx an entire 18 days ago, Ashlee Simpson did what every new mom does ... she went clubbing in West Hollywood.  —  Ash checked out her husband Pete Wentz's show at the Troubadour and then hightailed it next door to Foxtail for a little see and be scene action.

SOURCE: ‘Twilight’ Sequel Offer From Summit Out To Director Chris Weitz?  —  UPDATES Who Should Direct ‘Twilight’ Sequels?  —  Yes, he's had tremendous success working with tweens and teens (About A Boy as director and writer, American Pie as producer and uncredited director).

Britney's Dancers Getting Drug Tested  —  Who knew that the first thing you would hear after being hired to dance for Britney Spears would be, “Fill this, please.”  —  A source tells E! News that, in an effort to keep the on-track pop star free from negative influences …

The Dish Rag by Elizabeth Snead  —  « Hollywood worries about Bill Clinton's pants!  Main |  Start making your Golden Globes 2009 party plans!  »  —  Here's news that should serve to make every girl and woman feel much better about themselves.

Can You Say, ‘Senator Drescher’?  —  Everyone's favorite nanny is looking to take her famous Queens accent to a new home - the U.S. Senate, that is.  —  Fran Drescher tells PEOPLE she's offering up her name as a replacement for Senator Hillary Clinton, who has been nominated as Secretary of State.

Anne Hathaway's wedding wish  —  Anne Hathaway wants to get married.  —  The ‘Bride Wars’ star - who split from long-term boyfriend Raffaello Follieri earlier this year - hopes to settle down one day but admits her previous experiences have left her wary of commitment.