Jennifer Aniston exclusive: Friends star talks for the first time about John Mayer  —  She may have had her heart shredded by the world's sexiest man but Jennifer Aniston keeps coming back for more.  —  And this time the actress - who loved and lost Hollywood heartthrob Brad Pitt - hasn't just fallen head over heels again.

Exclusive: T.R. Knight negotiating 'Grey's Anatomy' exit  —  The revolving door at Grey's Anatomy has taken another shocking spin.  —  Multiple sources confirm that T.R. Knight has asked to be released from his contract, a request that both ABC and Grey's show-runner Shonda Rhimes appear poised to grant.

Ruffalo Dies  —  Scott Ruffalo, the brother of actor Mark Ruffalo, died last night after suffering a gunshot wound last week.  —  Brian Scofield and Shaha Mishaal Adham turned themselves in to the Bev Hills PD yesterday.  Adham was named a “suspect” and Scofield was named a"person of interest" in the shooting.

LA PAPER TRAIL  —  MARIAH Carey's wish may finally be coming true.  Spies in LA saw the songbird (above) coming out of a well-known ob/gyn's office on North Crescent Boulevard, “clutching what looked like a sonogram and being greeted by her entourage with cheers.  She was ebullient.”

Tom Cruise Tells Spencer Pratt He Made Wedding Mistake  —  The Hills - MTV Shows  —  In a pre-taped interview on Monday's i>Hills after-show, Tom Cruise was asked what advice he had for Spencer Pratt, who famously eloped with Heidi Montag Nov. 24.  —  Cruise said that Pratt …

Oprah Winfrey Admits to Tipping the Scales at 200 Lbs.  —  Oprah Winfrey Dec. 5  —  Having packed 40 pounds onto her former 160-pound self, Oprah Winfrey is declaring, “I'm mad at myself” because she's “fallen off the wagon.”  —  As the media mogul, 54, writes in the January issue …

Lily Allen Weighs in on ‘Crass’ Katy Perry  —  Lily Allen may have curbed her drinking as of late, but she isn't holding back on some of her other vices, namely trash talking and starting feuds.  The “Smile” singer, 23, is ticked at Katy Perry for supposedly making light of her weight …

Ashlee: Rock-a-Bye Bye Baby  —  After giving birth to son Bronx an entire 18 days ago, Ashlee Simpson did what every new mom does ... she went clubbing in West Hollywood.  —  Ash checked out her husband Pete Wentz's show at the Troubadour and then hightailed it next door to Foxtail for a little see and be scene action.

SOURCE: ‘Twilight’ Sequel Offer From Summit Out To Director Chris Weitz?  —  UPDATES Who Should Direct ‘Twilight’ Sequels?  —  Yes, he's had tremendous success working with tweens and teens (About A Boy as director and writer, American Pie as producer and uncredited director).

Britney's Dancers Getting Drug Tested  —  Who knew that the first thing you would hear after being hired to dance for Britney Spears would be, “Fill this, please.”  —  A source tells E! News that, in an effort to keep the on-track pop star free from negative influences …

Jennifer Hudson to begin filming video next week  —  NEW YORK - Jennifer Hudson is getting back to work.  —  Theola Borden, a spokeswoman for label J Records, says the singer is set to begin filming a video in Los Angeles next week for her next single, “If It Isn't Love.”

The Dish Rag by Elizabeth Snead  —  « Hollywood worries about Bill Clinton's pants!  Main |  Start making your Golden Globes 2009 party plans!  »  —  Here's news that should serve to make every girl and woman feel much better about themselves.

Anne Hathaway's wedding wish  —  Anne Hathaway wants to get married.  —  The ‘Bride Wars’ star - who split from long-term boyfriend Raffaello Follieri earlier this year - hopes to settle down one day but admits her previous experiences have left her wary of commitment.